Cefixon® 500 mg IM
Ceftriaxone Sodium USP
Cefixon® 1 g IM (Ceftriaxone) is highly stable to most β-lactamases, both Penicillinases and Cephalosporinases of Gram-positive and Gram-negative bacteria. The action of Cefixon® 1 g IM is bactericidal which inhibits the cell wall synthesis. It is most effective against the following microorganisms:
Gram-positive bacteria: Staphylococcus aureus (including penicillinase producing strains), Staphylococcus epidermis, Streptococci such as Streptococcus pneumoniae, Streptococcus bovis and Viridans streptococci.
Gram-negative bacteria: Escherichia coli, Haemophilus influenzae (including
penicillinase-producing strains), Neisseria gonorrhoeae, Neisseria meningitis,
Proteus mirabilis, Proteus vulgaris.
It is indicated for the treatment of sepsis, meningitis, abdominal infections (peritonitis, infections of the biliary and gastro-intestinal tracts), infections of the bones, joints, soft tissue, skin and/or wounds infections in patients with impaired defense mechanism, renal and urinary tract infections, respiratory tract infections, particularly pneumonia, and ear, nose and throat infections, genital infections including gonorrhoea.
DOSAGE & ADMINISTRATION
Adults and children over twelve years: The usual dosage is 1 to 2 g of Cefixon® 1 g IM administered once daily in 24 hours. In severe cases infections caused by moderately sensitive organisms, the dose may be increased to 4 g once daily.
Neonates, infants and children up to 12 years: For Neonates (up to 2 weeks) a daily dose of 20-50 mg/kg body weight, not to exceed 50 mg/kg on account of the immaturity of the infants is advised. For children with body weight of 50 kg or more, the usual adult dose should be used.
Elderly patients: The dosage recommended for adults require no modification in case of geriatric patients.
DURATION OF THERAPHY
The duration of therapy varies according to the course of the diseases. As with antibiotic therapy in general administration, Cefixon® 1g IM should be continued for a minimum of 48-72 hours after the patient has become afebrile or evidence of bacterial eradication has been obtained. For the treatment of gonorrhoea, a single intramuscular dose of 250 mg Cefixon® 1 g IM is recommended.
As with other Cephalosporins anaphylactic shock cannot be rubbed out even if a thorough patient history is taken. Anaphylactic shock requires immediate counter measures.
Diarrhoea, nausea, vomiting, stomatitis and glossitis
USE IN PREGNANCY AND LACTATION
Cefixon® 1 g IM is of pregnancy category B.
Cefixon® 1 g IM should be stored in a cool and dry place.
Cefixon® 500 mg IM Injection: Each box containing one vial of Ceftriaxone Sodium USP equivalent to Ceftriaxone 1 g and one ampoule of 2 ml Lidocaine Injection BP 1%.
Techno Drugs Ltd
® Cefixon is a registered trademark of Techno Drugs Ltd.