Avalone Tablets 500 MG

Avalone Tablets 500 mg

Category:

Product Description

Avalon

Composition:

Avalon 500 mg Tablet: Each film coated tablet contains Azithromycin Dihydrate USP equivalent to Azithromycin 500 mg.

Description: Azithromycin is an azalide, a subclass of macrolide antibiotics. It is derived from erythromycin. Azithromycin is used to treat or prevent certain bacterial infections, most often those causing middle ear infections, strep throat, pneumonia, typhoid, and sinusitis. In recent years, it has been used primarily to prevent bacterial infections in infants and those with weaker immune systems. It is also effective against certain sexually transmitted infections, such as non-gonococcal urethritis, chlamydia, and cervicitis.

Mode of action: Azithromycin prevents bacteria from growing by interfering with their protein synthesis. Azithromycin binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA. Nucleic acid synthesis is not affected.

Indication: Avalon is indicated for the treatment of infections caused by susceptible organism;

In lower respiratory tract infections including Bronchitis and Pneumonia,

Otitis media and Upper respiratory tract infections including Sinusitis, Pharyngitis and Tonsillitis.

Skin and soft tissue infections, Sexually transmitted diseases in men and women.

Avalon is indicated for the treatment of Urethritis and Cervicitis due to chalamidia trachomatis and Neisseeria gonorrhea.

Dosage and administration: Avalon tablet and suspension should be taken at least one hour before or two hours after meal.

Adults: Avalon should be taken as 500 mg once daily for 3 days or as an alternative, 5 days therapy should be taken 500 mg on day 1, then 250 mg once daily on days 2-5. For sexually transmitted diseases caused by chalamidia trachomatis, the dose of Avalon is 1 gm given as a double dose. Alternatively, 500 mg on day 1, then 250 mg once daily on days 2-3.

Elderly: Normal adult dose is recommended.

Children: For children aged over 6 months recommended dose is 10 mg/kg body weight once daily for 3 days.

If body weight is 15-25 kg: 200 mg once daily for 3 days.

Body weight 26-35 kg: 300 mg once daily for 3 days.

Body weight 36-45 kg: 400 mg once daily for 3 days.

If body weight over 45 kg normal adult dose is recommended.

Children less than six months of age Avalon is not recommended.

Side effects: Avalon is well tolerated with a low incidence of side effects. The side effects include Nausea, Vomiting, abdominal discomfort (pains/cramps), Flatulence, Diarrhea. Gastric lavage and general supportive measures indicated.

Precaution: Azithromycin should not be used in patients with hepatic diseases. Avoid concomitant administration with terfenadine or astemizole. Precaution should be taken in patients with more severe renal impairment.

Contraindication: Azithromycin in contraindicated in patients with known hypersensitivity to Azithromycin or any of the macrolide antibiotics. Co administration of ergol derivatives and azithromycin is contraindicated.

Overdose: Typical symptoms with macrolide antibiotics include hearing loss, severe nausea, Vomiting and Diarrhea, Headache, Dizziness, and skin rashes, and are reversible upon discontinuation of therapy.

Use in pregnancy and lactation: Animal reproduction studies have demonstrated that Azithromycin crosses the placenta, but have revealed no evidence of harm to the foetus. There are no adequate and well controlled studies in pregnant women. No data on secretion of azithromycin in breast milks available. So that Avalon should only be used in lactating mothers where adequate alternatives are not available.

Drug interaction: Azithromycin absorption is reduced in presence of food and antacid. So Avalon should be administered at least 1 hour before or 2 hours after the food and antacid taken

Storage: Store in a cool and dry place protected from light and keep out of the reach of children.

Commercial:

Avalon 500 mg Tablet: Box containing 1×6 film coated tablets in Alu Alu blister pack.

 

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