Apegestrol

Apegestrol

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Product Description

Brand NameApegestrol

Generic Name: Megestrol Acetate USP

Strength: Megestrol Acetate USP 160 mg

Description

Megestrol acetate  also known as 17α-acetoxy-6-dehydro-6-methylprogesterone,is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with   predominantly progestational and antigonadotropic effects. Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent.

Megestrol acetate acts predominantly as a potent agonist  of the progesterone receptor (PR) to exert its effects.

Megestrol acetate has Powerful antiandrogenic and antiestrogenic effects in humans at sufficient doses,capable of decreasing circulating  androgen  and estrogen concentrations to castrate levels in both sexes and significantly lowering the expression of the androgen receptor (AR) and the estrogen receptor (ER) in the body.

Indications:

Apegestrol can be used as an appetite stimulant for people experiencing loss of appetite and weigh loss because of advanced cancer.

Megestrolis also used to treat cancer anorexia-cachexia syndrome(CACS).

Also indicated in-

Recurrent and metastatic breat cancer,as second or third line hormonal agent.

Endometerial cancer

 

Dosage & Administration:

indication Dose
Appetite stimulant 160-800 mg /day
cachexia 400-800 mg/day
Endometrial carcinoma 40 to 320 mg/day in divided doses.at least 2 months of continuous treatment is required.
Breast cancer 160 mg /day,taken once daily.

Side effects :

May Include nausea, vomiting, impotence, edema, breakthrough bleeding, and shortness of breath. Rare and more severe side effects may include thrombophlebitis and pulmonary embolism.It may also cause glucocorticoid-related adverse effects such as adrenal insufficiency in some individuals and/or cases (especially if the medication is suddenly discontinued following prolonged use).

 

Contraindications:

Megestrol acetate should not be used in pregnancy under any circumstance as it crosses the placenta and malignantly affects the fetus.

Presentation:

Apegestrol is supplied as 160 mg tablet contained in a 3X8’s box

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