ANACORT INJ

Anacort inj

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Product Description

ANACORT®

Hydrocortisone BP

COMPOSITION

Each vial contains Hydrocortisone BP ( as sodium saccinate powder) 100mg.

MECHANISM OF ACTION

Hydrocortisone sodium succinate has the metabolic and anti-inflammatory actions. It is a glucocorticosteroid. Used in pharmacological doses, its actions supress the clinical manifestations of disease in a wide range of disorders.

 

INDIACTION

Primary or secondary adrenocortical insufficiency, Acute adrenocortical insufficiency, Shock unresponsive to conventional therapy, Congenital adrenal hyperplasia, Hypercalcemia associated with cancer, Nonsuppurative thyroiditis, Rheumatic Disorders, Dermatologic Diseases (Allergic States, Severe seborrheic dermatitis, Severe psoriasis, Pemphigus, Severe erythema multiforme), Control of severe or incapacitating allergic conditions (Bronchial asthma, Contact dermatitis, Atopic dermatitis, Serum sickness, Seasonal or perennial allergic rhinitis, Drug hypersensitivity reactions, Urticarial transfusion reactions, Acute noninfectious laryngeal edema), Ophthalmic Diseases (Herpes zoster ophthalmicus, Iritis, iridocyclitis, Chorioretinitis, Diffuse posterior uveitis and choroiditis, Optic neuritis), Gastrointestinal Diseases, Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, Loeffler’s syndrome, Aspiration pneumonitis, Hematologic Disorders (Acquired, autoimmune hemolytic anemia, Idiopathic thrombocytopenic purpura in adults, Secondary thrombocytopenia, Erythroblastopenia), Neoplastic Diseases (Leukemias and lymphomas in adults, Acute leukemia of childhood), Edematous States, Acute exacerbations of multiple sclerosis.

DOSAGE AND ADMINISTRATION

In most cases 50 to 100mg is sufficient. This may be varied according to the severity of the condition and the patient response. In xtreme emergencies and in shock like states the required dose may be injected intravenous over a period of 30 seconds. The response develops quickly and lasts from four to eight hours. If further emergency treatment is required,50mg doses may be given by intravenous infusion in 500 to 1000ml of normal saline or five percent glucose solution.

POSSIBLE SIDE EFFECTS

In the short ,high levels of hydrocortisone involve little risk of adverse reaction ,except that peptic ulceration may occure,or be aggravated. With continued use, signs of hydrocortism may become apparent.

CONTRAINDICATION

Systemic infections,unless specific anti-infective therapy is employed.

DRUG INTERACTION

Drugs that induce hepatic enzymes such as Phenobarbital, Phenytoin and Rifampin may increase the clearance of corticosteroids and may require increases in corticosteroid dose to achieve the desired response. Drugs such as Troleandomycin and Ketoconazole may inhibit the metabolism of corticosteroids and thus decrease their clearance. Therefore, the dose of corticosteroid should be titrated to avoid steroid toxicity.

PRECAUTION

Hydrocortisone should be used with caution in patients with a history of peptic ulceration as it increases the incidence of peptic ulceration. This drug should be used with caution in patients with cardiac failure, hypertension, glaucoma, diabetic mellitus and epilepsy.

STORAGE

Protect from light

PRESENTATIONS

Anacort injection: Vial containing 100mg hydrocortisone BP as hydrocortisone sodium succinate BP with 2 ml ampoule of water for injection.

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