Amoclav® is an antibacterial combination consisting of the antibiotic Amoxicillin
and the β-lactamase inhibitor Clavulanic Acid.
Indication and Usage
Amoclav® is indicated for short-term treatment of bacterial infections at the
- URTI (including ENT); e.g., tonsillitis, sinusitis, otitis media.
- LRTI; e.g., acute and chronic bronchitis, lobar and bronchopneumonia.
- Genito-urinary tract infections; e.g., cystitis, urethritis, pyelonephritis.
- Bone and joint infections; e.g., osteomyelitis.
- Other infections; e.g., septic abortion, puerperal sepsis, intra-abdominal
Dosage and Administrations
Dose of Tablets
Adults and children over 12 years:
The usual adult dose is one Amoclav® 625 Tablet every 12 hours or one Amoclav®375 Tablet every 8 hours.
Dose of Powder for Suspensions
Amoclav® Powder for Suspension:
1–6 years: 5 ml 3 times daily or 0.25 ml/kg 3 times daily
6–12 years: 10 ml 3 times dailyAmoclav® bid Powder for Suspension:
Dose of Injections:
Usually 1.2 g every 8 hours, increased in more severe infections to 1.2 g
every 6 hours.
Amoclav® should be used with care in patients on anti-coagulation therapy or
with severe hepatic dysfunction.
History of Penicillin hypersensitivity.
Urticarial and erythematous rashes sometimes occur.
In common with other beta-lactam antibiotics angioedema and anaphylaxis have been reported.
Use in Pregnancy and Lactation
Amoclav® in pregnancy is not recommended unless considered essential by the physician. During lactation, trace quantities of Amoxicillin can be detected in breast milk.
Prolongation of bleeding time and prothrombin time has been reported in
some patients receiving Amoclav®.
Amoclav® 375 Tablet: Each box contains 20 tablets in 2 X 10’s Alu-Alu form packs.
Each film coated tablet contains Amoxicillin Trihydrate BP equivalent to 250
mg Amoxicillin and Clavulanate Potassium USP equivalent to Clavulanic Acid125 mg.